![]() 1839:161-198.īecquerel A, Breschet G: Premier mémoire sur la chaleur animale. 10.1186/cc11211ĭavy J: Researches, Physiological and Anatomical. Altogether, this study illustrates the need to detect as early as possible the occurrence of infection among ICU patients to consider the use of antipyretic drugs.Įgi M, Kim JY, Suh GY, Koh Y, Nishimura N: Association of body temperature and antipyretic treatments with mortality of critically ill patients with and without sepsis: multi-centered prospective observational study. Although there was no statistically significant difference, still 12.5% of survivors received nonsteroidal anti-infl ammatory drugs versus 2.8% among the nonsurvivors. In this study only a few patients without sepsis received acetaminophen. The fact that, in contrast, high fever in patients without infection appears detrimental is also a key observation. Because fever occurs early during the survey of the patients with sepsis, it makes sense that its effect is easier to identify within this period. It is interesting to point out that when the Kaplan-Meier curve is analyzed over 2 weeks, the outcome is significantly better among patients with fever above 37.5☌ and below 39.4☌ (the adjusted odds ratio for 14 days provides the same statistical significance M Egi and colleagues, personal communication, February 2012). ![]() The work of Egi and colleagues nicely confirms this assertion. His claim was made with reference to numerous experimental animal models of severe infection in which the use of antipyretic drugs was shown to increase mortality. In 1995 Shann already warned the medical community that the use of antipyretics in sepsis could be detrimental.
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